Relationship between Serum IgE and Airway Responsiveness in Adults with Asthma

Almehmadi, Mazen; Alghamdi, Saad; Kelantan, Mashael; Khan, Suleman; Alsugoor, Mahdi H.; Tasleem, Samiyah; Bantun, Farkad; Alsaiari, Ahad Amer

doi:10.21608/eajbsc.2022.260470

Relationship between Serum IgE and Airway Responsiveness in Adults with Asthma

Document Type : Original Article

Authors

¹ Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia

² Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21912, Saudi Arabia.

³ Department of Preventive Medicine & Public Health, Hera General Hospital, Makkah, Saudi Arabia

⁴ Department of Health and Biological Sciences Abasyn University Peshawar, Khyber Pakhtunkhwa-25130-Pakistan

⁵ Department of Emergency Medical Services, Faculty of Health Sciences, AlQunfudah, Umm Al-Qura University, Makkah 21912, Saudi Arabia.

⁶ Department of Microbiology, University of Karachi-75270-Pakistan.

⁷ Department of Microbiology, Faculty of Medicine, Umm Al-Qura University, Makkah 21912, Saudi Arabia.

⁸ Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.

10.21608/eajbsc.2022.260470

Abstract

Several cell types and a wide variety of inflammatory mediators are involved in the chronic airway inflammation that characterizes asthma. The study aims to uncover a link between high serum immunoglobulin E IgE levels and childhood asthma. This cross-sectional study was conducted from March to July 2022 at Khyber Teaching Hospital Peshawar, Pakistan. Asthma patients traveling to the clinic's out-of-the-way chest medication branch were given a clear explanation of the review's goal, its system, and its security measures. This study included 65 patients. This study lists demographic, clinical, and useful characteristics. The research review included 18–60-year-old patients. 40 (66.67%) of our 60 patients were men, and 20 (33.33%) were women. Out of 60 cases, 56.67% had severe asthma. The researchers concluded that the serum levels of immunoglobulin E in asthmatics were much higher than those in normal patients. The severity of the patient's asthma was correlated with an increase in their IgE levels, on average.

Keywords