Investigate the Levels of Certain Adipokines in Patients with Diabetes in Kirkuk- Iraq

Mahmood, Diman M.; Amin, Haifaa M.; Hassan, Sara O.; Pirot, Aras Q.

doi:10.21608/eajbsc.2025.444126

Investigate the Levels of Certain Adipokines in Patients with Diabetes in Kirkuk- Iraq

Document Type : Original Article

Authors

¹ Sulaimani Polytechnic University, Collage of Health and Medical Technologies, Medical Laboratory Department, Kurdistan, Iraq.

² Sulaimani Polytechnic University, Technical Institute of Sulaimani, Radiology department. Kurdistan, Iraq.

³ Sulaimani Polytechnic University, Technical Institute of Sulaimani, Medical Laboratory Department, Kurdistan, Iraq.

10.21608/eajbsc.2025.444126

Abstract

Background: High blood sugar levels over an extended period are the primary sign of diabetes mellitus (DM), a metabolic disorder that falls under this class. It can be classified as one of the world's major diseases because it affects a large population and comes in two primary varieties: Type I and Type II. Objectives: The current study's goal is to assess many adipokines in patients with diabetes mellitus, including resistine, leptin, adiponectin and Apelin. Material and Methods: 50 patients (31 males and 19 females), age range (35-69) years (mean± SD) (49.7±13.1) years were enrolled in this study. All were consecutively admitted to the clinic at Azadi Teaching Hospital from January to March 2024. All patients had Type 2 Diabetes Mellitus (T2DM) as diagnosed by the physician. This study also included 25 healthy volunteers as a control group. Results: The current outcomes show that the concentration of Adiponectin demonstrated a significant (P <0.05) reduction in Diabetes Mellitus patients compared with healthy subjects. Also, the findings showed that, compared to healthy people, the Apelin concentration in DM patients was significantly (P <0.05) higher. Compared to healthy volunteers, the leptin levels in Diabetes Mellitus patients were significantly (P <0.05) higher. Compared to healthy volunteers, the resistin concentration in DM patients showed a significant (P <0.05) increase. Conclusion: In conclusion, the recent study found that leptin, resistin, and apelin levels were significantly increased in patients with DM compared to healthy people. However, adiponectin level was decreased.

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