The Impact of Aqueous Piliostigma thonningii Fruit Extract on Certain Biochemical Parameters on Male Wister Albino Rats

Agab, Somia A.; EL-Kamali, Hatil H.; Ibrahim, Mohamed AE.M.; Nour, Azhari A.; Al Foraih, Meisa; Kheiralla, Khalid E. K.; Shanwaz, Mohammed A.; Elsamani, Mohamed O.; Ali, Omar Y.M.; Mashnafi, Sultan Q.; Omer, Elgaili A.

doi:10.21608/eajbsc.2024.387169

The Impact of Aqueous Piliostigma thonningii Fruit Extract on Certain Biochemical Parameters on Male Wister Albino Rats

Document Type : Original Article

Authors

¹ Omdurman Islamic University (OIU), Department of Botany, Faculty of Science and Technology, Omdurman, Sudan.

² Al-Baha University, Department of Public Health, Faculty of Applied Medical Sciences, Al-Baha City, Saudi Arabia.

³ Al-Baha University, Department of Basic Medical Sciences, Faculty of Applied Medical Sciences, Al-Baha, KSA.

⁴ Department of Food Science and Nutrition, College of Health Sciences, Public Authority for Applied Education and Training, Shuwaikh Industrial, Kuwait.

⁵ Al-Baha-University, Department of Chemistry. Faculty of Science P.O. Box-1988, Al-Baha City,65527, KSA.

⁶ Deanship of Graduated Studies & Scientific Research, Kassala University, Kassala, Sudan.

10.21608/eajbsc.2024.387169

Abstract

Introduction: Piliostigma thonningii is a medicinal plant known for its diverse biological activities. This study examined the impact of the aqueous extract of P. thonningii fruits on biochemical parameters in a rat model. Methods: Male Wister Albino rats were administered varying doses (200, 500, and 1000 mg/kg) of the P. thonningii fruit aqueous extract for 28 days. The levels of liver enzymes (AST, ALT, and ALP), total protein, lipids, glucose, and indicators of renal function (urea, creatinine) were evaluated using standard assay kits and colorimetric methods. Results: The fruit aqueous extract of P. thonningii fruit had a significant effect in reducing serum AST levels (p<0.01) at doses of 500 and 1000 mg/kg, and ALT levels (p<0.05) at a dose of 1000 mg/kg. The treated groups exhibited a significant (p<0.05) decrease in total protein and cholesterol. The administration of the highest dose (1000 mg/kg) resulted in a notable decrease (p<0.01) in serum glucose levels, indicating the presence of hypoglycemic characteristics. There were no significant alterations detected in the levels of ALP, urea, and creatinine. Conclusion: The aqueous extract of P. thonningii fruits exhibited favorable positive effects on biochemical parameters in rats, indicating its potential therapeutic applications.

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