New N-Substituted Maleimide Drug Polymers: Synthesis, Drug Release and Antibacterial Activity

Document Type : Original Article

Authors

1 Department of Chemistry, College of Science, University of Babylon, P.O. Box 51002, Hilla, Iraq.

2 College of Pharmacy, Al-mustaqbal University, Babil Governorate, Iraq

Abstract

In this work, new substituted drugs polymerized as new homogenous polymers with study their medicinal properties to extend the controlled drug. The first step includes the preparation of compound N-(4-hydroxyphenyl) maleimide (D1) via a reaction of maleic anhydride with 4-aminophenol. Then compound (D1) was converted to maleimide phenol acetic acid ether (D2) which converted to its corresponding acyl chloride derivative which reacted with amino drugs (Ceftriaxone, Ciprofloxacin) afforded monomers (D3 and D4). Homogeneous polymers (D5 and D6) were prepared via free radical polymerization reaction of the monomers (D3, and D4) under nitrogen using Benzoyl peroxide (Bpo) as initiator. All these prepared monomers and polymers were characterized by FT-IR and 1H-NMR, 13C-NMR techniques and C.H.N.S . Study of the drug release behavior in acidic and basic media as well as the swelling ratio were achieved. The antibacterial activity and physical properties of all monomers and polymers were studied.

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