Alpha 1- Anti-chymotrypsin and Other Inflammatory Factors As Biomarkers for Alzheimer's Disease

Document Type : Original Article

Authors

1 M.B.Ch.B College of Medicine / University of Baghdad / Alkarkh General Hospital / Baghdad, Iraq.

2 Department of Biochemistry, College of Medicine / University of Baghdad / Baghdad, Iraq.

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease characterized by brain function disturbance. It is one of the disorders that affects old age group patients. However, the middle age group could be affected too. Till now, the etiology behind this disease is still obscured, although some researchers attributed it to a genetic factor. The pathology of AD reveals neuronal inflammation and degeneration following amyloid accumulation.
           The aim of this research is to study the relationship between AD & the level of some proteins like alpha1- anti chymotrypsin, high sensitive C-reactive protein and 1 interlukin-6 in the blood of participants. Patients, included in this study, are 130 one complaining of AD, they were divided into two groups according to their age. while 80 normal people are involved in this study as a control group. The serum of all patients and normal subjects were taken for detection of the level of alpha-1- anti chymotrypsin, high sensitive C-reactive protein and interlukin- 6.

Keywords

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology
Volume 15, Issue 2
December 2023
Pages 769-774

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