Synthesis, Characterization and Study of Anti-Bacterial Activity of Some New Bis-Heterocyclic Derivatives

Marhoon, Hasan M.; Zimam, Ezzat H.

doi:10.21608/eajbsc.2023.309591

Synthesis, Characterization and Study of Anti-Bacterial Activity of Some New Bis-Heterocyclic Derivatives

Document Type : Original Article

Authors

University of Kufa, Faculty of Science, Department of Chemistry, Al- Najaf / Iraq

10.21608/eajbsc.2023.309591

Abstract

In this research, some new 1,2,3-triazole derivatives of dapsone, have been prepared. The first step includes the preparation of Azo derivative by reaction of dapsone with the 4-Aminoacetophenone to produce azo compounds (A), then, the amino group of dapsone is converted to a diazonium salt and reacted with sodium azide to obtain the compound (B) Then, Chalcones (D1-D3); has been prepared through the reaction of an aromatic ketone with different aldehydes. The second step involves the reaction of chalcones derivatives (D1-D3) with compound (B) in the presence of copper (I) to obtain a 1,2,3-triazoline compound (H5 – H7). Different spectroscopy methods, such as FT-IR, ¹H-NMR, and ¹³C-NMR, were used to identify synthesized compounds.
The potential antibacterial activity of the synthesized heterocyclic derivatives has been finally tested as a third stage, using two types of bacteria (Staphylococcus aureus and Escherichia coli).

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