Determination of Azilsartan Medoxomil (anti-hypertension drug) by Cyclic Voltammetry Study and Biological Applications

Document Type : Original Article

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Faculty of Science, Department of Chemistry, University of Kufa, Iraq

Abstract

The purpose of this project is to examine the cyclic voltammetry (CV) analytical technique for the anti_thalassemia drug of azilsartan medoxomil by glassy carbon electrode (GCE) was described. The electrochemical performance of azilsartan medoxomil was studied by cyclic voltammetry technique. The ability of the electrode the determine azilsartan medoxomil under Optimized conditions in pH 12.699, scan rate 20mv/s, temperature 40 0C and interference have been studied. Where found the results that calibration curve of azilsartn medoxomil was linear in the concentrations 13.4×10-4-2.6×10-2 M, its detection limit was 8.46×10-11 M and LOQ was 2.82×10-10 M. The enthalpy ΔH was calculated to be (6.736 kJ. mol-1), and the entropy can be calculated to be (213.8 J. K‐1 mol‐1). The area of the electrode was calculated to be 0.0054 cm2 and the diffusion coefficient was 3.154×10-4 cm2sec-1. RSD% for bulk and form was less than 0.3%. The voltammogram for azilsartan medoxomil gives an irreversible process with a diffusion-controlled process. Finally, this technique has been applied to azilsartan medoxomil in pharmaceutical formulations. 

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