Molecular Evaluation of Long Non-Coding RNA (TUG1) in Systemic Lupus Erythematosus

Document Type : Original Article

Authors

1 Biochemistry Division, Chemistry Department, Faculty of science, Helwan University, Cairo, Egypt.

2 Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Abstract

Long non-coding RNAs play an important role in systemic lupus erythematosus. Our work purpose is to evaluate the level of LNC (TUG1) in SLE patients. This research includes 20 control and 70 SLE subjects. The serum level of LNC (TUG1) was measured by polymerase chain reaction. Down-expression of LNC (TUG1) was observed in SLE patients more than in control. A significant AUC of TUG1 level was recorded, which recommended that (TUG1) can act as a new biomarker for SLE determination.

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