Effect of Cerastes cerastes LAAO on Some Hematological Parameters in Hepatocellular Carcinoma-Induced in Rats

Document Type : Original Article

Authors

1 Department of Zoology, Faculty of Science (Boys branch), Al-Azhar University, Cairo, Egypt.

2 Nanotechnology Research Center (NTRC), The British University in Egypt (BUE), El-Sherouk City, Cairo 11837, Egypt. -Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Egypt.

3 Molecular Biology department, National Research Centre, Egypt.

Abstract

Background: One of the most prevalent cancers globally is hepatocellular carcinoma, which is also the most prevalent kind of primary liver cancer in Egypt. Diethyl nitrosamine (DEN) is a well-known, highly carcinogenic substance for the liver. It is well known that DENA damages DNA repair enzymes and is typically utilized to cause liver cancer in rats used as experimental animals.Objective: To assess the hematological parameters in hepatocellular carcinoma induced in rats treated with paclitaxel and l-amino acid oxidase (LAAO) (PAC).Materials and methods: 25 adult, mature, healthy male albino rats (Rattus rattus) with an average weight of (100 ± 10 g) were used in this investigation. The rats were divided into 5 groups, each with 5 rats. At the conclusion of the experiment, hematological parameters were examined for all groups.Results: When treated with LAAO and PAC, the results demonstrated that all hematological parameters significantly changed from their respective levels in the control group. As compared to the DENA(HCC) group, the results revealed improvements for several criteria.
Conclusion: WBCs, RBCs, Hb, and PLTs were all enhanced by the administration of LAAO and PAC. etc.

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