Document Type : Original Article
Authors
1
Department of Biology, Faculty of Life and Natural Sciences, Djillali Liabes University, Sidi-Bel-Abbes, Algeria. -Laboratory of Molecular Microbiology, Proteomics and Health, Djillali Liabes University, Sidi-Bel-Abbes, Algeria. epartment of Biology, Faculty of Life and Natural Sciences, Djillali Liabes University, Sidi-Bel-Abbes, Algeria
2
The Obstetric and Gynaecologic Hospitalist, Sidi-Bel-Abbes, Algeria.
3
Department of Anatomopathology, University Hospital Center, Sidi-Bel-Abbes, Algeria
4
Department of General Surgery, University Hospital Center, Sidi-Bel-Abbes, Algeria
Abstract
Background: Constituting the most frequent malignant tumor among women in Algeria, breast cancer represents a heterogeneous and multifactorial disease. The current study aimed to determine the risk factors and clinicopathological features of breast cancer in women from Sidi-Bel-Abbes region, Northwestern Algeria. Patients and Methods: A descriptive retrospective study was carried out by reviewing data from the medical records of patients who underwent a mastectomy at the level of the maternity hospital of Sidi-Bel-Abbes, in the period 2020-2022. Results: Based on 118 breast cancer patients’ data records, the mean age at diagnosis was 52.92±13.69 years. Patients with blood group O+ (38.1%) were the most affected. The majority of patients were married women (88.1%). The prevalent disease recorded in patients' medical history was hypertension (23.7%). Further, 45.8% of patients were premenopausal, and 12.7% were nulliparous. The mean age at menarche was 12.47±0.73 years. The most common histological type was invasive ductal carcinoma (77.1%), SBR grade II was mainly found in 65.3% of cases, T2 was the main tumor size (64.4%), and 3.4% of patients had metastatic disease. The expression of estrogen receptors and progesterone receptors was respectively positive in 68.6% and 64.6% of cases. Luminal B was the predominant molecular subtype (55.1%). Conclusion: In our region, breast cancer is mainly diagnosed in younger and middle-aged women at an advanced stage, and numerous risk factors influence breast cancer occurrence. Therefore, Better identification of breast cancer risk factors and the biological mechanisms in which they are involved can be effective in improving breast cancer prevention.
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