Ameliorative Effect of The Essential Oil of Syzygium aromaticum in Wistars Rats Exposed to Aluminum Chloride

Adli, Djallal Eddine Houari; Ziani, Kaddour; Kourat, Dallal; Brahmi, Mostapha; Souidi, Sendous Adjila; Naar, Asma; Kahloula, Khaled; Slimani, Miloud

doi:10.21608/eajbsc.2022.277234

Ameliorative Effect of The Essential Oil of Syzygium aromaticum in Wistars Rats Exposed to Aluminum Chloride

Document Type : Original Article

Authors

¹ Laboratory of Biotoxicology, Pharmacognosy and Biological Valorization of plants (LBPVBP), Department of Biology, Faculty of Sciences, University of Dr Moulay Tahar, Saida, Algeria

² Laboratory of Biotoxicology, Pharmacognosy and Biological Valorization of plants (LBPVBP), Department of Biology, Faculty of Sciences, University of Dr Moulay Tahar, Saida, Algeria-Department of Biology, Faculty of Science and Technology, University of Relizane 48000, Algeria

10.21608/eajbsc.2022.277234

Abstract

The objective of this study, on the one hand, is to evaluate the impact of aluminium intoxication, on the biochemical and hematological approaches of adult Wistar rats, on the other hand, to test the efficacy of Syzygium aromaticum essential oil (CEO) in restoring or not the harmful effects of the studied metal with a daily intraperitoneal injection of 0.1 ml CEO/kg. The extraction of the essential oil from S.aromaticum by hydro-distillation allowed us to obtain CEO with a yield of 10.18%. Chronic exposure to aluminum chloride at a concentration of 100mg/kg in rats decreased body and organ weights (Liver, Kidney) compared to controls. The intoxication also revealed a disruption of various biochemical parameters, including liver (TGO, TGP), and kidney (urea, creatinine) biochemical assays, Thus, the concentration of aluminium in the intoxicated group is high in the blood. Also, the results show a correction in the values of these parameters following the administration of CEO compared to those of exposed animals. CEO also corrected the shape of the affected blood cells after intoxication to aluminium.

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