Efficiency of Clove Oil Nanoemulsion in Modulating Titanium Dioxide-Induced Some Disorders in the lung of the Mice

The goal of the current investigation was to assess the potential therapeutic efficacy of administering clove oil nanoemulsion to treat certain pulmonary problems that male mice's exposure to titanium dioxide nanoparticles (TiO2 NPs) had generated.
              It has been demonstrated that titanium dioxide nanoparticles (TiO2 NPs) might have detrimental effects on health and lead to diseases of the respiratory system. Although clove oil possesses anti-inflammatory and antioxidant qualities, its pungent taste, chemical instability, and limited water solubility place restrictions on how much of its potential can be utilised. To get over this limitation, a nanoemulsion of clove oil (NE-CLV) was created. Material and methods: Five groups, each with ten mice, were formed from the fifty mature male mice. SOD and GPx are determined as antioxidants and MDA as an indicator of oxidative stress.  IL-6 and TNF-α levels were determined in the lung tissue. Genotoxicity was evaluated by using a laddered DNA fragmentation assay. Histopathological examination using hematoxylin and eosin stain. Results: SOD and GPx were decreased. While, MDA, IL-6 and TNF-α levels were increased in the injected Titanium dioxide nanoparticles group. Co-administration of the clove oil nano-emulsion ameliorates the changes in these parameters and the histopathological changes. Also, reduced the DNA damage caused by nano titanium and restored the integrity of the genomic DNA. Conclusion: This study's goal was to ascertain whether clove oil nanoemulsion (NE-CLV) could reduce the toxicity of TiO2 NPs by regulating oxidative changes, restoring them to their original state, and preventing genotoxic damage. Therefore, it appears that NE-CLV can be used as a helpful hemoprotective to prevent the toxicity that is brought on by exposure to TiO2 NPs.