The Therapeutic Effect of Cinnamomum cassia Essential Oil Against Mncl2-Induced Nephrotoxicity in Developing Wistar Rats

Brahmi, Mostapha; Adli, Djallal Eddine; Benrguieg, Mokhtar; Arabi, Wafaa; Houari, Hmida; Talatizi, Mustapha; Slimani, Miloud; Kahloula, Khaled

doi:10.21608/eajbsc.2022.270217

The Therapeutic Effect of Cinnamomum cassia Essential Oil Against Mncl2-Induced Nephrotoxicity in Developing Wistar Rats

Document Type : Original Article

Authors

¹ Department of Biology, Faculty of Science, Laboratory of biotoxicology, pharmacognosy and biological valorization of plants University of Dr Moulay Tahar Saida, 20000, Algeria -Department of Biology, Faculty of Science and Technology, University of Relizane 48000, Algeria

² Department of Biology, Faculty of Science, Laboratory of biotoxicology, pharmacognosy and biological valorization of plants University of Dr Moulay Tahar Saida, 20000, Algeria

³ Institue of Veterinary Sciences Ibn-Khaldoun University Tiaret 14000, Algeria.

10.21608/eajbsc.2022.270217

Abstract

The present study aimed to evaluate the protective effect of Cinnamomum cassia essential oil on nephrotoxicity induced by manganese chloride (4.79mg/ml) in young Wistar rats during the development period. Wistar rat animals were exposed to manganese through maternal watering on a postnatal day (PND) 1 to (PND) 21. After weaning, the rats exposed to manganese received injections of Cinnamomum cassia essential oil (0.1 ml/kg) for 21 days. The concentration of manganese in the renal tissues was significantly increased compared to control rats. However, the levels of renal markers such as urea, uric acid, and creatinine were significantly increased in the blood after manganese chloride administration. Manganese-induced oxidative stress in renal tissue was indicated by decreased levels of superoxide dismutase, catalase, and glutathione peroxidase respectively. Histologically, the kidney showed several tissue alterations such as necrosis of the glomeruli and tubules. The administration of Cinnamomum cassia essential oil considerably attenuated the previous biochemical damage in serum and kidney tissue as well as histological and cellular modifications. In this study, it can be concluded that the Cinnamomum cassia essential oil showed a nephroprotective effect.

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