Department of Biology, Laboratoire de Nutrition, Pathologie, Agrobiotechnologie et Santé, Faculty of Natural and Life Sciences, Djillali Liabes University, Sidi-bel-Abbes, Algeria.
Objective: The present work investigates the interrelationship of food intakes of micronutrients and amino acids with the apolipoprotein (apo) B / apo A1 ratio as a potential indicator of atherosclerosis risk in patients with obesity and/or type 2 diabetes (T2D). Methods: A cross-sectional comparative study was performed on 285 participants divided into three groups; normal-weight type 2 diabetics, overweight/obese type 2 diabetics and overweight/obese non-diabetics. Anthropometric and blood pressure were measured. Biochemical parameters were evaluated and the apo B/apo A1 ratio was calculated. Food dietary intakes were assessed using a validated 3-days food record. The Association between intakes of micronutrients (vitamins and minerals) and amino acids was studied using Principal Component Analysis (ACP). Results: Significant differences were revealed with respect to age, fasting and postprandial blood glucose, triglycerides and glycated hemoglobin (Hba1c) (p < /em><0.005). In normal-weight diabetics, ACP showed that the highest apo B/apo A1 ratios were positively associated with branched-chain amino acids intake, vitamins E and B6, and calcium, zinc and phosphorus levels. In overweight/obese T2D patients, amino acid intakes were associated with vitamins B2 and B12 and minerals; phosphorus and zinc. However, results in overweight/obese patients without diabetes revealed that amino acid intakes were specifically correlated with vitamin D. Conclusion: Micronutrients and amino acids play a pivotal role in the development of cardiovascular risk in obese and/or diabetics. Branched-chain amino acids, B and D vitamins, as well as calcium and zinc, show considerable associations with higher apo B/apo A1 ratio and therefore with atherosclerosis.
Mustapha, D., & Boumediene, K. (2022). Micronutrients and Amino Acids Food Intakes and Their Associations with Obesity, Type 2 Diabetes and Apo B/Apo A1 Ratio in Middle-Aged Algerian Adults. Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology, 14(1), 383-397. doi: 10.21608/eajbsc.2022.234591
MLA
Diaf Mustapha; Khaled Meghit Boumediene. "Micronutrients and Amino Acids Food Intakes and Their Associations with Obesity, Type 2 Diabetes and Apo B/Apo A1 Ratio in Middle-Aged Algerian Adults", Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology, 14, 1, 2022, 383-397. doi: 10.21608/eajbsc.2022.234591
HARVARD
Mustapha, D., Boumediene, K. (2022). 'Micronutrients and Amino Acids Food Intakes and Their Associations with Obesity, Type 2 Diabetes and Apo B/Apo A1 Ratio in Middle-Aged Algerian Adults', Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology, 14(1), pp. 383-397. doi: 10.21608/eajbsc.2022.234591
VANCOUVER
Mustapha, D., Boumediene, K. Micronutrients and Amino Acids Food Intakes and Their Associations with Obesity, Type 2 Diabetes and Apo B/Apo A1 Ratio in Middle-Aged Algerian Adults. Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology, 2022; 14(1): 383-397. doi: 10.21608/eajbsc.2022.234591
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