Anti-nephrotoxic and Antioxidant Efficiency of Rosmarinus Officinalis Extract Against Isoniazid®-Induced Nephropathy in Adult Male Albino Rats.

Document Type : Original Article

Authors

1 Zoology Department, Faculty of Science, Al-Azhar University, Egypt

2 Basic Centre of Science, Misr University for Science and Technology, Egypt

3 Medical Physiology Department, National Research Centre, Egypt

4 Pathology Department, National Research Centre, Egypt

5 Chemistry Department, Fayoum University, Cairo, Egypt

Abstract

Tuberculosis accounted as a serious disease throughout the world, and nephrotoxicityis one of the most serious side effects of main anti-tuberculosis drugs. The objective of this study was to explore the nephro-protective potential of rosemary aqueous extract against Isoniazid®-induced nephrotoxicity. Adult male Wistar albino rats (150-170g) were randomly divided into four groups: 1) normal rats, 2) rats administrated with rosemary extract (440mg/kg/day), 3) rats received Isoniazid® (50mg/kg/day), and 4) rats treated with Isoniazid® in combination with rosemary extract. After eight weeks, the results revealed that rosemary extract along with Isoniazid® minimized the Isoniazid®-induced renal deterioration; this was evidenced by the significant reduction in serum levels of urea, creatinine, uric acid, TNF-α, IL-1β and Na+ as well as kidney MDA, nitric oxide and DNA fragmentation .This was matched with  a marked enhancement in calcium and K+ serum levels. and so kidney GSH, and Na+/K+ ATPase activity. Moreover, the histopathological findings showed a potential protection as the extract succeeded in prevention of Isoniazid® induced tissue degenerations. In conclusion, rosemary extract could play a beneficial role for the prevention of Isoniazid®-nephrotoxicity via its anti-oxidative and anti-nitrosative voltage.

Keywords

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology
Volume 10, Issue 2
December 2018
Pages 45-61

Files

Share

How to cite

Statistics