Association between Lipid Levels and Short-Term Heart Rate Variability (HRV) In Type 2 Diabetes

Document Type : Original Article


1 Department of Physiology, PSG Institute of Medical Sciences and Research, Peelamedu, Coimbatore, Tamil Nadu, India – 641004

2 PSG Institute of Medical Sciences and Research, Peelamedu, Coimbatore, Tamil Nadu, India – 641004.

3 MD (Community medicine) PGDHP, Institute of Community Medicine, Madras Medical College, Chennai – 600003

4 MS (ENT) (AIIMS), FRCS (Eng), FRCS (Ed), OT ENT Centre, R S Puram, Coimbatore – 641002.


Background: There are plenty of studies available to demonstrate the effect of diabetes on short-term Heart Rate Variability (HRV) but not enough about lipids, especially in our region. Hence, we aimed to study the influence of total cholesterol and individual lipid fractions on short-term HRV in type 2 diabetics.
Methods: As per the set criteria, 70 newly diagnosed type 2 diabetics were recruited and grouped based on their cholesterol levels. Both the time domain and the frequency domain measures of short-term HRV were acquired and subjected to statistical analysis. This was a cross-sectional observational study.
Results: Elevated total cholesterol group showed a reduction in Standard deviation of all NN intervals (SDNN) and High Frequency (HF) power and an increase in Low-Frequency power / High-Frequency power (LF/HF) ratio in comparative analysis. Similarly, the high low-density lipoproteins (LDL) group showed a decrease in square root of the mean of the sum of the squares of the differences between adjacent NN intervals (SDNN) and RMSSD but a rise in LF/HF ratio. Moreover, total cholesterol is negatively correlated with SDNN, RMSSD, and HF power while total cholesterol and LDL are positively correlated with LF/HF ratio. Total cholesterol, LDL, and triglycerides had an independent association with HF.
Conclusions: Our study shows higher levels of total cholesterol, LDL and triglycerides decrease cardiovagal activity. Hence, based on this we conclude abnormal lipid levels depress HRV