Neurotoxic and Oxidative Stress Impacts in Male Albino Rats Exposed to Single Dose of Abamectin

Document Type : Original Article

Author

Mammalian and Aquatic Toxicology Department, Central Agricultural Pesticides Laboratory, Agricultural Research Center, Giza

Abstract

Background: The widespread use of pesticides in public health and agriculture operations has led to significant environmental degradation and potential health risks. It's worth noting that the main reason for toxicity with most pesticides, especially insecticides like is to attack nervous system components. Aim: this study achieved to study the effect of single oral and dermal sub-lethal exposure of abamectin as a neurotoxic compound on acetylcholinesterase (AchE) and oxidative stress biomarkers in male albino rat's brains. Methods: experimental rats were divided into three groups as control, oral and dermal (15 rat each). The tested dose was ½ of LD50 for oral and dermal experiments. Results: single abamectin exposure by oral or dermal is connected with neurotoxicity in exposed rats as evidenced by a marked reduction in. Acetylcholinesterase (AChE) activity and induction of oxidative stress. The oxidative stress biomarkers lipid and protein oxidation (MDA and PC) were significantly increased. While antioxidant biomarkers, glutathione (GSH) glutathione peroxidase (GPx) and superoxide dismutase (SOD) were markedly declined in both oral and dermal exposure. GST was increased markedly in brain tissues. Conclusion: this study through light on neuro and oxidative impact of abamectin after a single exposure (acute effect). SO, awareness of the importance of responsible use of pesticides must be implemented for reducing the hazard impact of agrochemicals.

Keywords

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology
Volume 13, Issue 2
December 2021
Pages 63-72

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