Sustainable Hypoglycemic Action of Neem Oil on Male Rabbits and Its Impact on Some Glucose Regulating Hormones

Hassanein, Hamdy M. A.; Salem, Fatma Elzahraa H.; Farag, Masoud A.; Ahmed, Amira M.

doi:10.21608/eajbsc.2021.191605

Sustainable Hypoglycemic Action of Neem Oil on Male Rabbits and Its Impact on Some Glucose Regulating Hormones

Document Type : Original Article

Authors

¹ Zoology Department, Faculty of Science, Sohag University, Egypt

² Zoology and Entomology Department, Faculty of Science, Helwan University, Cairo, Egypt

³ Biology Department, Faculty of Science and Arts, Azzaytona University, Libya

⁴ Chemistry Department, Faculty of Science, Sohag University, Egypt

10.21608/eajbsc.2021.191605

Abstract

Neem tree (Azadirachta indica) is one of the crucial medical plants found in tropical and sub-tropical regions around the world especially in dry forests in India, Pakistan, Sri Lanka and Burma. The present study deals with the assessment of the sustainable hypoglycemic action of Azadirachta indica in rabbits after using two sub-lethal doses of neem oil extract, low dose (1/10 LD₅₀) and high dose (1/4 LD₅₀). Blood glucose level, insulin, cortisol, adrenaline and noradrenaline were measured through the treatment period for 60 days followed by 30 days withdrawal period. The results showed that neem oil has an obvious hypoglycemic effect and has a noticeable rule in raising the serum levels of the investigated hormones. Nonetheless, the observed changes were still potent during the withdrawal period. In conclusion, it can be deduced that the high dose of neem oil is more efficient than the low dose of Azadirachta indica which may serve as an important alternative source in the remedy of diabetes mellitus involved in dropping increased blood glucose during diabetes, after taking all precautionary measures to avoid the toxicity of the extract.

Keywords