Physiological effects of envenomation by two different doses of the viper Echis coloratusis crude venom on biochemical parameters in serum of Guinea pigs at different times.

Salman, Muhammad M. A.

doi:10.21608/eajbsc.2009.16302

Physiological effects of envenomation by two different doses of the viper Echis coloratusis crude venom on biochemical parameters in serum of Guinea pigs at different times.

Document Type : Original Article

Author

Muhammad M. A. Salman

Zoology Department, Faculty of Science, South Valley Univesity, Qena, Egypt

10.21608/eajbsc.2009.16302

Abstract

The eastern carpet viper Echis
coloratusis widely distributed from Africa (eastern Egypt). In the present study the effects of crude venom of the viper
Echis coloratusis on serum biochemical
parameters of guinea pigs. Adult
male guineapigs
(550 ± 25 g body weigh) were divided into three groups (15 each). In the
control group, guinea pigs were interaperitoneally (i.p) injected with 50 µL
saline solution. The second group was i.p.injected
with 0.1µgm/g b.w. of crude venom
in 50 µL saline solutions. The third group was i.p.injected
with 0.2 µgm/g. b.w. of the crude
venom in 50 µL saline solution. The results indicated that the injection of
crude venom of the viper Echis
coloratusis induced a significant decrease in total serum protein,
albumin, globulin and uric acid within
1, 2 and 4 hrs. after injection. In contrast, the
levels of glucose, cholesterol, triglycerides, urea and creatinine were increased
significantly in envenomated Guinea pigs. Viper Echis
coloratusis crude venom caused
hepatic and renal dysfunction in envenomated Guinea pigs.

Keywords