Assessment of Oral Cellular proliferative activity among Toombak Dipper in Al-Obeyed City, Sudan

Alobaid, Awad Eljeed Abugooda; Elemam, Ibrahim Bakhit Yousef; Alsheikh, Mohammed Abed Algader; Mahmud, Abdalhafeez Osman; Ahmed, Hussain Gadelkarim

doi:10.21608/eajbsc.2014.16037

Assessment of Oral Cellular proliferative activity among Toombak Dipper in Al-Obeyed City, Sudan

Document Type : Original Article

Authors

¹ Department of Histopathology and Cytology, Medical Laboratory Sciences, Al-yarmouk College, Khartoum, Sudan.

² Department of Histopathology and Cytology, Medical Laboratory Sciences, Al-yarmouk College, Khartoum, Sudan

³ Department of Pathology, College of Medicine, University of Hail, KSA

10.21608/eajbsc.2014.16037

Abstract

Background: Many factors have been identified as important causative agents that responsible for the development of oral precancerous and cancerous lesions. In Sudan, Toombak have been identified as a major risk factor. Therefore, the aim of this study was to assess the cellular proliferative activity that associated with Toombak use. Methodology: In this study 75 apparently healthy individuals were selected for this study, of whom 50 were currently Toombak users (cases) and 25 were non-Toombak users (controls), Pap. Method and Silver technique were used for the staining of oral smears.
Results: Cytological atypia was identified in 10 cases and 4 controls. The mean count NORs count was 4.6 in cases and 2.2 in controls.
Conclusion: Toombak is a major risk for occurrence of cellular proliferative activity features that may progress in to oral precancerous or cancerous lesions.

Keywords