The Variant Allele Frequency of the lncRNA Prostate Cancer-Associated Noncoding RNA 1 (PRNCR1) rs1456315 C/T Polymorphism in Saudi Population and Colorectal Cancer Risk

Document Type : Original Article

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Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha University, Albaha- KSA

Abstract

Single-nucleotide polymorphisms (SNPs) in long noncoding RNA (lncRNA) genes are associated with the onset and progression of multiple cancers in humans. These SNPs are potential biomarkers for predicting cancer risk. The variable frequency of the lncRNA prostate cancer-associated noncoding RNA 1 (PRNCR1) rs1456315 C/T polymorphism may affect different ethnic groups differently, however, the information lacks for the Saudi population. The aim of this study was to assess the allelic distribution and frequency of the PRNCR1 rs1456315 C/T polymorphism in the Saudi Arabian population, as well as compare it to other populations around the world. PUBMED (Medline) and other related web-databases were referred to extract data from epidemiological studies performed in different ethnic groups. The frequency of PRNCR1 rs1456315 variant allele (C) was found to be 34.62% and a significantly different frequency was observed for the USA (p=0.01), Iran (p < /em><0.007) and China (p=0.01) ethnicity, when the Saudi occurrence is compared to those populations. Present results reveal a distinct pattern of lncRNA prostate cancer-associated noncoding RNA 1 (PRNCR1) rs1456315 polymorphism variant allele in the Saudi Arabian population, which may be due to ethnic differences. The findings could assist in the risk assessment of people harbouring risk allele of rs1456315 SNP and their subsequent cancer susceptibility.

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