Effect of Fullerene C60 (NPs) on Cyclophosphamide-Induced Hepato and Cardiac Toxicity in Male Albino Rats.

Document Type : Original Article


Department of Zoology, Faculty of Science, SouthValleyUniversity, Qena, Egypt


Background: Toxicity due to drugs used for neoplastic disorders is documented in previous studies. Cyclophosphamide (CP) is a widely used as anticancer drug, which could cause toxicity of normal cells through its toxic metabolites. The fullerene family, especially Fullerene C60 nanoparticles (NPs) can be utilized in many and different biological fields. We evaluated the protective role of Fullerene C60 (NPs) in the toxicity induced by cyclophosphamide.
Methods: The activities of serum Liver marker enzymes; alanin amino transferase (ALT) and aspartate amino transeferase (AST), alkaline phosphatase (ALP). T. protein, Albumin, serum heart marker enzymes; Lactate dehydrogenase (LDH) and creatinine phosphokinase (CK) were determined.
Results: Toxicity of the organs like heart, and liver was proved from increases of ALT, AST, ALP, LDH and CK values and a decrease in T. protein and Albumin in cyclophosphamide (200 mg/kg a single dose) administered rats, Fullerene C60NPsdissolved in olive oil (0.8 mg/ml) oral treatment will show enhancement against toxicity induced by (CP)at a dose of 4 mg/kg body weight daily for 10 days.
Conclusion: In this study, we wish to report that, the in vivo treatment of Fullerene C60 (NPs) was improved the biochemical changes caused by cyclophosphamide-induced toxicities. These results have importance in the fields of medicine. This may open the way for the biomedical applications of C60in treatment of cancer, neurodegenerative disorders, and ageing.