%0 Journal Article %T Phytochemical analysis and inhibitory effects of extract of young fruits of Ficus palmate on some pathogenic microbes %J Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology %I Egyptian Society of Biological Sciences %Z 2090-0767 %A Alrumman, Sulaiman A. %A Moustafa, Mahmoud F. %A Hesham, Abd El-Latif %A Alamri, Saad A. %A Hashem, Mohamed %D 2014 %\ 06/01/2014 %V 6 %N 1 %P 131-139 %! Phytochemical analysis and inhibitory effects of extract of young fruits of Ficus palmate on some pathogenic microbes %K Ficus palmata %K Gram positive bacteria %K Gram negative bacteria %K Candida species %R 10.21608/eajbsc.2014.16054 %X The present study was conducted to determine the antimicrobial activityof various extracts of young fruits of Ficus palmata Forsk. against someGram positive and Gram negative bacteria and Candida species using theagar well diffusion method.  Resultsshowed that the cold water extract had no inhibitory effect against anytested microbes, while the hot water extract inhibited the microbial growth(12.5%). Methanol, chloroform, petroleum ether or acetone extract of the dryfruits inhibited microbial growth (37.5%), while diethyl ether extractinhibition was 12.5%. Methanol extract of fresh fruitsinhibited themicrobial up to 75%. However, the chloroform and petroleum ether extractsinhibited microbial growth by 62.5% and 37.5%, respectively. Gas Chromatogram-Mass spectrometry (GC-MS) analysis of hexanextract of the young fruits of Ficus palmata was carried out to identify its phytochemical constituents. Four chemicalconstituents have been identified: diethyl phthalatewas the major compound (86.19%) (Retention time 16.65), and cyclohexasiloxane, dodecamethyl-, (Rt 12.77), 1,3-dimethyl-2-nitrobenzene (Rt 14.91) and benzamide (Rt15.07) were the minor constituents (4.47, 7.96 and 1.36%, respectively). Itcould be concluded that the extractof young fresh fruits of Ficus palmata and its bioactive components, in particular diethyl phthalate, could be of phytopharmaceutical importance as anantimicrobial agents %U https://eajbsc.journals.ekb.eg/article_16054_fd1aa28c215e26c36c6145ace0df64ec.pdf